This bar graph shows that mice raised on a high-fat diet have diminished response to nicotine. Mice fed a normal diet spent most of a 15-minute test period on the side of a cage in which they had been given nicotine, whereas mice fed a high-fat diet showed no such preference. The data for each category follows:

• Time spent on nicotine associated side for mice fed a normal diet: approximately 625 seconds
• Time spent on nicotine associated side for mice fed a high-fat diet: approximately 390 seconds
• Time spent on non-nicotine associated side for mice fed a normal diet: approximately 290 seconds
• Time spent on non-nicotine associated side for mice fed a high-fat diet: approximately 560 seconds