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7 1/2 week embryo, 7.5 week embryo, seven and a half week embryo

Interactive Prenatal Development Timeline

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BODY SYSTEMS/REGIONS SELECTION MENU
Nervous System Cardiovascular Musculoskeletal Early Events
Special Senses Respiratory Skin Growth Parameters
Movement Gastrointestinal Endocrine General
Facial Genitourinary Blood & Immune "Gee Whiz" Facts
 



Unit 1:   The First Week
     
   
Unit 3:   2 to 3 Weeks
     
  • (2 weeks, 1 day):
  • Early Events3 germ layers
  • Early EventsBilateral symmetry
  • Early EventsCloacal membrane
  • Early EventsPrechordal plate
  • Early EventsPrimitive groove
  • Early EventsRostral-caudal orientation
  • (2 weeks, 2 days): Carnegie Stage 7
  • Early EventsAllantoic diverticulum
  • Early EventsAmnion with two cell layers
  • Early EventsNotochordal process
  • Early EventsSecondary villi
  • GenitourinaryAllantoic diverticulum
  • GenitourinaryPrimordial germ cells
  • Blood & ImmuneErythroblasts in umbilical vesicle
  • Blood & ImmuneThree types of hemopoietic cells in
  • Blood & Immune    umbilical vesicle
  • (2 weeks, 3 days):
  • EndocrineAnlage of the thyroid
  • (2 weeks, 4 days): Carnegie Stage 8
  • Early EventsConnecting stalk
  • Early EventsPrimitive pit
  • Nervous SystemNeural ectoderm
  • Nervous SystemNeural groove and folds
  • Nervous SystemNotochordal and neurenteric canals
  • Nervous SystemNotochordal plate
  • Special SensesPrechordal plate with 1 retinal field
  • CardiovascularUteroplacental circulation well
  • Cardiovascular    established
  • GastrointestinalForegut, midgut, and hindgut
  • "Gee Whiz" FactsBrain is first organ to appear
  • (2 weeks, 5 days):
  • Special SensesPrechordal plate with 2 retinal
  • Special Senses    fields
  • (2 weeks, 6 days): Carnegie Stage 9
  • GeneralSomites 1 - 3 pairs of somites
  • Early EventsCephalic and caudal folds
  • Early EventsPrimitve streak reaches neurenteric
  • Early Events    canal
  • Nervous SystemCaudal eminence
  • Nervous SystemForebrain, midbrain, and hindbrain
  • Nervous SystemHindbrain with four rhombomeres
  • Nervous SystemIsthmus rhomencephali demarcates
  • Nervous System    midbrain and hindbrain
  • Nervous SystemNeural crest
  • Nervous SystemNeural groove deepens substantially
  • Nervous SystemPrimary neuromeres
  • Special SensesOtic disc
  • FacialFirst pharyngeal pouch
  • FacialStomodeum forming
  • CardiovascularBlood vessels emerge independently in
  • Cardiovascular    umbilical vesicle, embryo proper,
  • Cardiovascular    amnion, and connecting stalk
  • CardiovascularCardiogenic plate, cardiac jelly,
  • Cardiovascular    myocardial mantle, and endocardial
  • Cardiovascular    plexus
  • CardiovascularDorsal aortae (paired)
  • CardiovascularFirst pair of aortic arches
  • CardiovascularPaired pericardial cavities
  • CardiovascularPaired tubular heart
  • CardiovascularSeptum transversum
  • GastrointestinalForegut
  • MusculoskeletalFirst somites
  • Blood & ImmuneNumerous blood islands in umbilical
  • Blood & Immune    vesicle
   
Unit 5:   4 to 5 Weeks
     
  • (4 weeks, 4 days): Carnegie Stage 14
  • Nervous SystemAdenohypophysis
  • Nervous SystemAll 16 secondary neuromeres
  • Nervous SystemCerebellum with intermediate layer
  • Nervous SystemCerebral hemispheres
  • Nervous SystemDi-telencephalic sulcus
  • Nervous SystemDorsal and ventral thalami
  • Nervous SystemDorsal funiculus
  • Nervous SystemMamillary region
  • Nervous SystemMedial and lateral longitudinal
  • Nervous System    fasciculi
  • Nervous SystemMedian ventricular eminence
  • Nervous SystemPontine flexure
  • Nervous SystemPreoptico-hypothalamo-tegmental tract
  • Nervous SystemRhombic lip
  • Nervous SystemSulcus medius
  • Nervous SystemSynencephalon
  • Nervous SystemTegmentum
  • Nervous SystemTentorium cerebelli, medial portion
  • Nervous SystemTorus hemisphericus (TH)
  • Nervous SystemVelum transversum
  • Nervous SystemVentral longitudinal fasciculus
  • Special SensesEyes located on sides of head
  • Special SensesLens pit
  • Special SensesOptic cups
  • CardiovascularEpicardium
  • CardiovascularSinu-atrial (SA) node
  • RespiratoryRight and left main stem bronchi
  • GenitourinaryUreteric buds
  • (4 weeks, 5 days): Carnegie Stage 15
  • Nervous SystemAdult lamina terminalis
  • Nervous SystemAmygdaloid area
  • Nervous SystemCerebellar plate
  • Nervous SystemFirst axodendritic synapses in
  • Nervous System    cervical spinal cord
  • Nervous SystemFirst nerve fibers
  • Nervous SystemHabenular nucleus
  • Nervous SystemHabenulo-interpeduncular tract
  • Nervous SystemHypothalamic sulcus
  • Nervous SystemHypothalamus
  • Nervous SystemLateral ventricle
  • Nervous SystemLateral ventricular eminence
  • Nervous SystemLocus caeruleus
  • Nervous SystemLongitudinal zones in diencephalon
  • Nervous SystemMesencephalic tract of CN 5
  • Nervous SystemMost cranial nerves seen
  • Nervous SystemPostoptic recess
  • Nervous SystemSclerotomic material around notochord
  • Nervous System    (rhombomere D level)
  • Nervous SystemSubthalamus
  • Nervous SystemSuperior colliculi
  • Nervous SystemSuperior medullary velum
  • Nervous SystemSupramamillary commissure
  • Nervous SystemSynapses among motor neurons in
  • Nervous System    spinal cord
  • Nervous SystemTectobulbar tract
  • Nervous SystemTentorium
  • Nervous SystemThird ventricle
  • Nervous SystemTrigemino-cerebellar tract
  • Special SensesLens vesicles beneath surface
  • Special SensesNasal pits
  • Special SensesOptic chiasma
  • Special SensesOptic stalk
  • FacialLateral and medial nasal processes
  • Facial    bilaterally
  • CardiovascularBlood vessels penetrate diencephalon
  • CardiovascularCoronary arteries (terminal end)
  • CardiovascularPosterior communicating arteries
  • MusculoskeletalVertebrae well defined
  • (4 weeks, 5 days - 5 weeks, 3 days):
  • CardiovascularAortic and pulmonary valves
  • (5 weeks):
  • CardiovascularPacemaker cells in sinus venosus
  • RespiratoryArytenoid and epiglottal swellings
  • RespiratoryLobar pattern mimics adult pattern
  • RespiratoryT-shaped laryngeal inlet
  • GastrointestinalCircular muscles in esophagus
   
Unit 7:   6 to 7 Weeks
     
  • (6 weeks, 2 days): Carnegie Stage 18
  • Early EventsEmbryo with dorsal concavity
  • Nervous SystemArchistriatum
  • Nervous SystemCerebrospinal fluid production begins
  • Nervous SystemChoroid folds in fourth ventricle
  • Nervous SystemChoroid plexuses in fourth and
  • Nervous System    lateral ventricles
  • Nervous SystemDentate nucleus in internal
  • Nervous System    cerebellar swellings
  • Nervous SystemExternal cerebellar swellings contain
  • Nervous System    flocculi
  • Nervous SystemFour amygdaloid nuclei
  • Nervous SystemHippocampus reaches olfactory region
  • Nervous SystemNucleus ambiguus of the vagus (CN10)
  • Nervous SystemProsencephalic septum
  • Nervous SystemRed nucleus
  • Nervous SystemSubstantia nigra
  • Nervous SystemSupraoptic commissure
  • Nervous SystemTwo or more semicurcular ducts
  • Nervous SystemVomeronasal organ. nerve, and
  • Nervous System    ganglion
  • Special SensesNasolacrimal duct
  • Special SensesNerve fibers in retina
  • Special SensesOptic fibers
  • Special SensesPrimordium of stapes surrounds
  • Special Senses    stapedial artery
  • FacialBucconasal membrane
  • CardiovascularOrigin of left coronary artery
  • CardiovascularSeptum secundum and foramen ovale
  • GastrointestinalSubmandibular glands
  • (6½ weeks):
  • MusculoskeletalOssification in mandible & maxilla
  • SkinVolar pads on palms
  • (6 weeks, 5 days): Carnegie Stage 19
  • Nervous SystemChoana
  • Nervous SystemGanglion of nervus terminalis
  • Nervous SystemGlobus pallidus externus in the
  • Nervous System    diencephalon
  • Nervous SystemIntermediate layer in dorsal thalamus
  • Nervous SystemLateral recesses in fourth ventricle
  • Nervous SystemLemniscal decussation
  • Nervous SystemMedial accessory olivary nucleus
  • Nervous SystemNuclei of forebrain septum
  • Nervous SystemNucleus accumbens
  • Nervous SystemNucleus accumbens
  • Nervous SystemOccipital pole of cerebral
  • Nervous System    hemispheres
  • Nervous SystemSubcommissural organ
  • Special SensesCartilaginous styloid process
  • Special SensesCochlear nuclei
  • Special SensesOptic fibers enter chiasmatic plate
  • CardiovascularCirculus arteriosus (Circle of
  • Cardiovascular    Willis) complete
  • CardiovascularOrigin of right coronary artery
  • MusculoskeletalBeginnings of occipital and sphenoid
  • Musculoskeletal    bones
  • SkinThree semicircular ducts
  • (6 weeks, 6 days):
  • GastrointestinalMembrane blocking rectum ruptures
  • (7 weeks):
  • MovementHead rotates
  • CardiovascularHeart rate peaks (165 to 170
  • Cardiovascular    beats/minute)
  • RespiratoryBronchopulmonary segments complete
  • GenitourinaryOvaries
  • Growth ParametersCrown-heel length 2.2 cm
   
Unit 9:   8 to 9 Weeks
     
   
Unit 11:   10 to 11 Weeks
     
   
Unit 13:   3 to 4 Months
     
   
Unit 15:   5 to 6 Months
     
  • (21 weeks):
  • SkinPeriderm disappears
  • SkinSratum corneum
  • (22 weeks):
  • Nervous SystemBehavioral states
  • Special SensesCornea structure
  • (23 weeks):
  • Growth ParametersBrain weight 100 grams
  • (24 weeks):
  • Growth ParametersCrown-heel length 34.5 cm
   
Unit 17:   7 to 8 Months
     
   
Unit 19:   9 Months to Birth
     
  • (37 weeks):
  • GastrointestinalFetus drinks an estimated 15 oz (or
  • Gastrointestinal    450cc) of amniotic fluid/day
  • (38 weeks):
  • GeneralBirth
  • Nervous SystemSpinal cord ends at third lumbar
  • Nervous System    vertebrae
  • Growth ParametersBrain weight 350 grams
  • Growth ParametersCrown-heel length 50 cm
  • Growth ParametersHead circumference 35 cm
  • "Gee Whiz" FactsHeart beats 54 million times before
  • "Gee Whiz" Facts    birth
  • "Gee Whiz" FactsThis timeline has more than 3.1
  • "Gee Whiz" Facts    million configurations
   
Fertilization
Play Movie - Cell Division
Week 1 ends
Play Movie - 1 to 2 weeks, implantation and HCG
Week 2 ends
Play Movie - 2 to 3 week embryo, amnion, germ layer
Week 3 ends
Play Movie - 3 to 4 week embryo, folding of the embryo
Week 4 ends
Play Movie - 4 to 5 week embryo, The Heart in Action
Week 5 ends
Play Movie - 5 to 6 week embryo, hand plates develop
Week 6 ends
Play Movie - 6 to 7 week embryo, hand movement
Week 7 ends
Play Movie - 7 to 8 week embryo, fingers, toes
Week 8 ends
Play Movie - 8 to 9 week fetus, reflexive movement
Week 9 ends
Play Movie - 9 to 10 week fetus, sucking, swallowing
Week 10 ends
Play Movie - 10 to 11 week fetus, eyes roll, yawns
Week 11 ends
Play Movie - 11 to 12 week fetus, nails, fingerprints
Month 3 ends
Play Movie - 3 to 4 month fetus, the rooting reflex
Month 4 ends
Play Movie - 4 to 5 month fetus, bronchial tree
Month 5 ends
Play Movie - 5 to 6 months fetus, responds to sound
Month 6 ends
Play Movie - 6 to 7 month fetus, response to light
Month 7 ends
Play Movie - 7 to 8 month fetus, behavioral states
Month 8 ends
Play Movie - 8 to 9 month fetus, firm hand grasp
Month 9 ends
Play Movie - 9 months to Birth, ready for Birth
Birth
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Unit 2:   1 to 2 Weeks
     
  • (1 week, 1 day):
  • Early EventsBilaminar embryonic disc
  • EndocrineHCG (human chorionic gonadotropin)
  • (1 week, 2 days): Carnegie Stage 5b
  • Early EventsChorion
  • Early EventsEarly decidual reaction
  • Early EventsExocoelomic membrane
  • Early EventsIsolated trophoblastic lacunae
  • Early EventsPrimary umbilical vesicle
  • Growth ParametersEmbryonic disc 0.1 mm diameter
  • (1 week, 2 days - 20 weeks):
  • EndocrineCorpus luteum of pregnancy
  • (1 week, 4 days): Carnegie Stage 5c
  • Early EventsLongitudinal axis
  • Early EventsTrophoblastic vascular circle
  • (1 week, 5 days):
  • Early EventsImplantation complete
  • Growth ParametersEmbryonic disc diameter: 0.15 to 0.20
  • Growth Parameters    mm
  • (1 week, 6 days): Carnegie Stage 6
  • Early EventsAmnion with single cell layer
  • Early EventsChorionic villi
  • Early EventsPrimitive streak and node
  • Early EventsSecondary umbilical vesicle
  • Blood & ImmuneAngiogenesis in chorionic mesoblast
  • Blood & ImmuneBlood islands in umbilical vesicle
  • Blood & ImmuneBlood vessels in villi
   
Unit 4:   3 to 4 Weeks
     
  • (3 weeks, 1 day): Carnegie Stage 10
  • General4 to 12 pairs of somites
  • Nervous SystemChiasmatic plate
  • Nervous SystemForebrain with neuromeres D1 and D2
  • Nervous SystemMesencephalic flexure
  • Nervous SystemNeural tube
  • Nervous SystemSegment D in rhombencephalon
  • Nervous SystemSome secondary neuromeres
  • Nervous SystemTelencephalon
  • Special SensesOptic primordia
  • Special SensesOptic primordia fill neuromere D2
  • Special SensesOptic sulcus in forebrain
  • Special SensesOtic pits
  • Special SensesOtic plates
  • FacialHyoid arch
  • FacialMandibular arch and maxillary process
  • FacialOropharyngeal membrane
  • FacialPharyngeal arches 1 and 2
  • FacialPharyngeal cleft 1
  • FacialSecond pharyngeal cleft and pouch
  • CardiovascularAtria (right and left) far apart
  • CardiovascularEndocardial tubes fuse forming
  • Cardiovascular    tubular heart
  • CardiovascularHeart begins beating
  • CardiovascularLeft ventricle, right ventricle,
  • Cardiovascular    conotruncus
  • CardiovascularPericardium
  • CardiovascularSinus venosus
  • CardiovascularTubular heart begins folding
  • CardiovascularUmbilical arteries
  • CardiovascularUmbilical veins (right and left)
  • RespiratoryPharyngeal groove and ridge with
  • Respiratory    laryngotracheal sulcus
  • RespiratoryRespiratory primordium
  • GastrointestinalHepatic plate
  • GastrointestinalMidgut emerging
  • EndocrineThyroid primordium emerges from floor
  • Endocrine    of pharynx
  • (3 weeks, 1 day - 4 weeks):
  • Early EventsBody cavities
  • Early EventsFolding of the embryo
  • (3 weeks, 2 days):
  • GenitourinaryNephrogenic cord emerges (at 10
  • Genitourinary    somites)
  • (3 weeks, 3 days): Carnegie Stage 11
  • General13 to 20 pairs of somites
  • GeneralSegmentation of mesoblast alongside
  • General    neural tube bilaterally
  • Nervous SystemAdenohypophysial primordia
  • Nervous SystemFacio-vestibulocochlear ganglia
  • Nervous SystemGlossopharyngeal and vagal ganglia
  • Nervous SystemLamina terminalis
  • Nervous SystemMesencephalon contains tectum and
  • Nervous System    tegmentum
  • Nervous SystemNeural crest production and migration
  • Nervous System    continue
  • Nervous SystemNeurohypophysial primordia
  • Nervous SystemNotochord
  • Nervous SystemRostral neuropore closes
  • Nervous SystemTrigeminal ganglia
  • Special SensesNasal plate
  • Special SensesOptic evagination (starting at 14
  • Special Senses    somites)
  • Special SensesOptic neural crest
  • Special SensesOptic sulcus
  • Special SensesOptic vesicle (17 to 19 somites)
  • Special SensesOptic vesicles form
  • Special SensesOtic vesicle
  • FacialMaxillary and mandibular processes
  • Facial    (bilaterally)
  • FacialMembrane between future mouth and
  • Facial    throat may begin to rupture
  • CardiovascularAngiogenesis along surface of central
  • Cardiovascular    nervous system
  • CardiovascularAortic sac
  • CardiovascularAtrioventricular canal
  • CardiovascularCapillary plexus begins forming
  • Cardiovascular    around brain and spinal cord
  • CardiovascularConotruncus
  • CardiovascularConus cordis emerging from right
  • Cardiovascular    ventricle
  • CardiovascularEndocardium
  • CardiovascularHeart contractions produce
  • Cardiovascular    peristaltic blood flow
  • CardiovascularInterventricular septum
  • CardiovascularPrimordium of myocardium
  • CardiovascularSinus venosus separating from left
  • Cardiovascular    atria
  • CardiovascularTrigeminal and otic arteries
  • GastrointestinalCystic primordium
  • GastrointestinalHepatic diverticulum
  • GastrointestinalLiver
  • GenitourinaryCloacal membrane
  • GenitourinaryMesonephric duct emerges from
  • Genitourinary    nephrogenic cord
  • GenitourinaryNephric vesicles
  • GenitourinaryPrimordial germ cells begin moving
  • Genitourinary    from umbilical vesicle to hindgut
  • (3 weeks, 3 days - 5 weeks, 6 days):
  • Nervous SystemAll eight rhombomeres
  • (3 weeks, 5 days): Carnegie Stage 12
  • General21 - 29 pairs of somites
  • GeneralEctodermal ring complete
  • GeneralProgressively C-shaped embryo
  • Nervous SystemBrain involves 40% of neural tube
  • Nervous SystemCaudal neuropore closes
  • Nervous SystemCaudal neuropore closes
  • Nervous SystemEmbryonic commissural plate
  • Nervous SystemHypoglossal cord enters pharyngeal
  • Nervous System    arch 4
  • Nervous SystemHypoglossal nucleus
  • Nervous SystemMamillary recess
  • Nervous SystemMarginal layer in rhombencephalon
  • Nervous SystemMesencephalic flexure at 90 degrees
  • Nervous SystemMesencephalon with two neuromeres: M1
  • Nervous System    and M2
  • Nervous SystemMotor neurons in basal plate of
  • Nervous System    rhomencephalon
  • Nervous SystemNeural cord within caudal eminence
  • Nervous SystemNeurofibrils form in rhombencephalon
  • Nervous SystemPrimordia of ventral thalamus and
  • Nervous System    subthalamus in diencephalon
  • Nervous SystemSulcus limitans
  • Nervous SystemSulcus limitans in midbrain
  • Nervous SystemTelencephalon medium
  • Special SensesNasal discs form part of ectodermal
  • Special Senses    ring
  • Special SensesOptic vesicles covered by sheath
  • Special SensesOtocyst nearly closed
  • FacialOropharyngeal membrane is ruptured
  • FacialPharyngeal arches 1, 2, and 3
  • FacialPharyngeal arches with dorsal and
  • Facial    ventral parts
  • CardiovascularAtrioventricular canal
  • CardiovascularCommon cardinal veins (right and
  • Cardiovascular    left)
  • CardiovascularHeart circulates blood to and from
  • Cardiovascular    central nervous system, umbilical
  • Cardiovascular    vesicle, and chorion
  • CardiovascularHepatic primordium with abundant
  • Cardiovascular    vascular plexus
  • CardiovascularHepatocardiac channels (right and
  • Cardiovascular    left)
  • CardiovascularInternal carotid arteries
  • CardiovascularRight and left dorsal aorta fuse
  • Cardiovascular    forming descending aorta
  • CardiovascularRostral and caudal cardinal veins
  • Cardiovascular    along brain and spinal cord feeding
  • Cardiovascular    common cardinal veins
  • CardiovascularSeptum primum and foramen primum
  • Cardiovascular    sometimes present
  • CardiovascularSinu-atrial foramen prevents backflow
  • Cardiovascular    into sinus venosus
  • CardiovascularSinus venosus collects veinous blood
  • Cardiovascular    from entire embryo
  • CardiovascularUnidirectional circulation
  • CardiovascularVitelline arteries and veins
  • RespiratoryCervical sinus
  • RespiratoryLung bud
  • RespiratoryTracheo-esophageal septum
  • GastrointestinalAlimentary epithelium invades stroma
  • Gastrointestinal    of liver
  • GastrointestinalAlimentary epthelium proliferates in
  • Gastrointestinal    primordia of stomach, liver, and
  • Gastrointestinal    dorsal pancreas
  • GastrointestinalFirst part of pancreas
  • GastrointestinalGastric portion of foregut elongates
  • Gastrointestinal    (25 to 28 somites)
  • GastrointestinalOmental bursa
  • GastrointestinalUmbilical vesicle elongates
  • MusculoskeletalUpper limb primordium at level of
  • Musculoskeletal    somites 8 to 10
  • EndocrineTelopharyngeal bodies
  • (3 weeks, 5 days - 4 weeks):
  • RespiratoryLaryngotracheal groove
  • (3 weeks, 5 days - 7 weeks, 1 day):
  • Nervous SystemSacrocaudal spinal cord formation
  • Nervous System    (secondary neurulation)
  • (4 weeks): Carnegie Stage 13
  • Early EventsAmnion surrounds connecting stalk and
  • Early Events    vitelline stalk
  • Early EventsUmbilical cord
  • Nervous SystemAdenohypophysial pouch
  • Nervous SystemCerebellum
  • Nervous SystemCommissural plate
  • Nervous SystemCommon afferent tract
  • Nervous SystemFourth ventricle
  • Nervous SystemInterstitial nucleus (part of medial
  • Nervous System    longitudinal fasciculus)
  • Nervous SystemIsthmus rhombencephali (a new
  • Nervous System    neuromere)
  • Nervous SystemMost cranial nerve ganglia
  • Nervous SystemOculomotor and trochlear nuclei
  • Nervous SystemTerminal-vomeronasal neural crest
  • Special SensesBasement membrane of otic disc
  • Special Senses    surrounds otic vesicle
  • Special SensesEndolymphatic appendage
  • Special SensesOtic vesicle closed
  • Special SensesRetinal and lens discs
  • FacialLower lip forms from merging of
  • Facial    mandibular processes
  • CardiovascularAortic arches 4 and 6
  • CardiovascularAtrioventricular bundle
  • CardiovascularAtrioventricular cushions
  • Cardiovascular    (rostroventral and caudodorsal)
  • CardiovascularBasilar and vertebral arteries
  • CardiovascularCardiac contractions still under
  • Cardiovascular    myogenic control
  • CardiovascularCeliac artery, superior and inferior
  • Cardiovascular    mesenteric arteries
  • CardiovascularCirculatory system "well established"
  • CardiovascularContractions well coordinated and
  • Cardiovascular    sequential from sinus venosus to atria
  • Cardiovascular    to ventricles
  • CardiovascularDuctus venosus
  • CardiovascularGas exchange through placenta begins
  • CardiovascularGelatinous reticulum (or cardiac
  • Cardiovascular    mesenchyme)
  • CardiovascularHeart chambers bulging with fluid
  • CardiovascularHeart now functions as two parallel
  • Cardiovascular    pumps
  • CardiovascularHeart with right and left ventricles
  • CardiovascularHepatocardiac vein
  • CardiovascularMyocardium wall 3 to 4 cells thick
  • CardiovascularSeptum primum, foramen primum
  • CardiovascularSmall arteries emerging throughout
  • Cardiovascular    mesoderm
  • CardiovascularVentricle walls trabeculated
  • CardiovascularVitelline veins empty exclusively
  • Cardiovascular    into hepatic plexus
  • RespiratoryBronchial buds
  • RespiratoryEmbryonic stage begins
  • RespiratoryRight and left lung buds
  • RespiratoryTrachea
  • GastrointestinalDiverticulum ilei marks division
  • Gastrointestinal    between foregut and hindgut
  • GastrointestinalIntestines growing in length
  • GastrointestinalPleuroperitoneal canals
  • GastrointestinalStalk of umbilical vesicle lengthens
  • Gastrointestinal    and narrows
  • GastrointestinalStomach assumes shape of a spindle
  • GastrointestinalUmbilical vesicle at height of
  • Gastrointestinal    development
  • GastrointestinalVentral pancreas
  • GastrointestinalVitelline duct
  • GenitourinaryGlomeruli emerge in mesonephros
  • GenitourinaryMesonephric duct attached to cloaca
  • GenitourinaryNephric tubules now S-shaped
  • GenitourinaryPrimordial germ cells migrate to
  • Genitourinary    mesonephric ridges
  • GenitourinaryPrimordial germ cells number several
  • Genitourinary    hundred
  • GenitourinaryUrorectal cleavage line
  • MusculoskeletalDiaphragm primordia
  • MusculoskeletalUpper & lower limb buds
  • MusculoskeletalUpper and lower limb buds
  • SkinMelanoblasts in epidermis
  • SkinPeriderm
  • EndocrineThyroid bilobed and attached to
  • Endocrine    pharynx by thryoglossal duct
  • Blood & ImmuneSpleen primordia
  • Blood & ImmuneThymic primordia
   
Unit 6:   5 to 6 Weeks
     
  • (5 weeks, 2 days): Carnegie Stage 16
  • Nervous SystemAll cranial nerves identifiable
  • Nervous SystemArchipallium, paleopallium, and
  • Nervous System    neopallium
  • Nervous SystemCochlear nerve present
  • Nervous SystemCommissure of the trochlear nerve
  • Nervous SystemDiencephalic subthalamic nucleus
  • Nervous SystemEpiphysis cerebri
  • Nervous SystemGlial cells identifiable adjacent to
  • Nervous System    neurons
  • Nervous SystemHypoglossal nerve reaches tongue
  • Nervous SystemInfundibular recess and infundibulum
  • Nervous SystemMarginal ridge
  • Nervous SystemNeurohypophysial outgrowth
  • Nervous SystemOlfactory tubercle
  • Nervous SystemPontine flexure deepens
  • Nervous SystemPrimordial plexiform layer in area of
  • Nervous System    future temporal lobe
  • Nervous SystemRetinal fissure closes
  • Special SensesOlfactory fibers enter brain
  • Special SensesOlfactory tubercle present
  • FacialFrontonasal prominence
  • CardiovascularAtrioventricular (AV) node
  • CardiovascularCircle of Willis almost complete
  • RespiratoryEpiglottis
  • EndocrineThyroid detaches from pharynx
  • EndocrineThyroid with right and left lobes
  • Endocrine    connected by an isthmus
  • (5½ weeks):
  • FacialDental lamina
  • (5½ weeks - 6 weeks):
  • MovementSubtle movement begins
  • (5 weeks, 4 days - 6 weeks):
  • CardiovascularMitral and tricuspid valves
  • (5 weeks, 5 days - 7 weeks, 1 day):
  • SkinMelanocytes in epidermis
  • (5 weeks, 6 days): Carnegie Stage 17
  • Nervous SystemAll 39 somite pairs present
  • Nervous SystemAll spinal nerves present
  • Nervous SystemCapillaries between adenohypophysis
  • Nervous System    and hypothalamus
  • Nervous SystemCommissure of the oculomotor nerves
  • Nervous SystemCortical nucleus in amygdaloid body
  • Nervous SystemDentate and isthmic nuclei in
  • Nervous System    cerebellum
  • Nervous SystemDura begins forming in basal area
  • Nervous SystemFirst hint of septal nucleus
  • Nervous SystemFrontal and tempororal poles of
  • Nervous System    cerebral hemispheres
  • Nervous SystemGustatory fibers separate from common
  • Nervous System    afferent tract
  • Nervous SystemHemispheric stalk
  • Nervous SystemIntermediate layer in tectum
  • Nervous System    mesencephali
  • Nervous SystemInterventricular foramen
  • Nervous SystemSpinal cord reaches caudal tip of
  • Nervous System    body
  • Nervous SystemSubarachnoid space
  • Nervous SystemSynapses in spinal cord between
  • Nervous System    interneurons and primary afferent
  • Nervous System    neurons
  • Special SensesBlind nasal sac
  • Special SensesCell islands in olfactory tubercle
  • Special SensesCrescentic lens cavity
  • Special SensesNostril becomes continuous with nasal
  • Special Senses    sac
  • Special SensesPrimary lens fiber
  • Special SensesPrimordia of orbital muscles
  • FacialGlobular process emerges from each
  • Facial    medial nasal process
  • CardiovascularAnterior choroid artery
  • GastrointestinalAppendix
  • MusculoskeletalCartilage in occipital sclerotomes
  • Musculoskeletal    (1-4)
  • MusculoskeletalHypoglossal foramen through
  • Musculoskeletal    sclerotome 4
  • (6 weeks):
  • FacialTooth buds (Deciduous)
  • CardiovascularInferior vena cava
  • CardiovascularInternal and external jugular veins
  • CardiovascularPortal vein
  • GastrointestinalIntestines fill base of umbilical
  • Gastrointestinal    cord
  • MusculoskeletalHandplates develop subtle flattening
  • SkinMilk lines
  • Blood & ImmuneBlood formation & lymphocytes in
  • Blood & Immune    liver
  • Growth ParametersCrown-heel length 1.6 cm
   
Unit 8:   7 to 8 Weeks
     
  • (7 weeks, 1 day): Carnegie Stage 20
  • Nervous SystemCerebral hemispheres expand beyond
  • Nervous System    lamina terminalis
  • Nervous SystemCerebral peduncles
  • Nervous SystemCuneate and gracile decussating
  • Nervous System    fibers
  • Nervous SystemInterpeduncular groove
  • Nervous SystemMedial septal nucleus
  • Nervous SystemNigrostriatal fibers
  • Nervous SystemNucleus of diagonal band
  • Nervous SystemSeptum verum
  • Special SensesOptic commissure
  • FacialFacial processes no longer
  • Facial    distinguishable
  • (7 weeks, 1 day - 8 weeks):
  • GastrointestinalFolds in stomach wall
  • (7 weeks, 2 days):
  • CardiovascularCoronary arteries and veins complete
  • (7 weeks, 3 days): Carnegie Stage 21
  • Nervous SystemAnterior and inferior horns of
  • Nervous System    lateral ventricle
  • Nervous SystemC-shaped lateral ventricle
  • Nervous SystemCerebral hemispheres cover more than
  • Nervous System    half of diencephalon
  • Nervous SystemCortical plate within primordial
  • Nervous System    plexiform layer
  • Nervous SystemGlial and neurilemmal (Schwann) cells
  • Nervous System    within cranial nerves
  • Nervous SystemGlobal pallidus internus
  • Nervous SystemHippocampus
  • Nervous SystemInternal fiber layer of cerebellum
  • Nervous SystemLateral olfactory tract
  • Nervous SystemPineal recess
  • Nervous SystemPrimordium of dentate nucleus
  • Nervous SystemPyrimadal cells in hippocampus
  • Nervous SystemSubthalamic nucleus proper,
  • Nervous System    entopeduncular nucleus, and globus
  • Nervous System    pallidus externus within subthalamus
  • Nervous SystemSulcus transversus rhombencephali
  • Nervous SystemVentral part of lateral geniculate
  • Nervous System    body
  • FacialCartilaginous nasal septum
  • CardiovascularAnterior and middle cerebral arteries
  • CardiovascularAnterior and posterior choroid
  • Cardiovascular    arteries
  • MusculoskeletalChondrocranium with dorsum sellae and
  • Musculoskeletal    hypophysial fossa
  • MusculoskeletalDens (of second cervical vertebrae)
  • (7½ weeks):
  • CardiovascularEKG pattern similar to adult
  • SkinPlantar pads toes
  • SkinVolar pads on fingertips
  • (7 weeks, 5 days): Carnegie Stage 22
  • Nervous SystemCerebral hemispheres cover 75% of
  • Nervous System    diencephalon
  • Nervous SystemClaustrum
  • Nervous SystemCommissural plate thickens
  • Nervous SystemCortical plate expanding rapidly
  • Nervous SystemFolds in roof of third ventricle
  • Nervous SystemInternal capsule with connections to
  • Nervous System    epithalamus, dorsal thalamus, and
  • Nervous System    mesencephalon
  • Nervous SystemNerve fibers between neopallial
  • Nervous System    subplate and internal capsule
  • Nervous SystemPutamen
  • Nervous SystemSpinothalamic tract
  • Nervous SystemThalamocortical fibers
  • CardiovascularIntradural veins (sinuses)
  • MusculoskeletalEndolymphatic, jugular, and
  • Musculoskeletal    hypoglossal foramina
  • MusculoskeletalOptic foramen, foramen rotundum,
  • Musculoskeletal    internal acoustic foramen
  • (8 weeks): Carnegie Stage 23, Embryonic Period Ends
  • Nervous SystemBrain highly complex
  • Nervous SystemBrain represents 43% of embryo
  • Nervous SystemCaudate nucleus and putamen within
  • Nervous System    corpus striatum
  • Nervous SystemCerebellar commissures
  • Nervous SystemCerebellum with external germinal
  • Nervous System    layer
  • Nervous SystemChoroid plexus now lobular
  • Nervous SystemCortical plate covers nearly all of
  • Nervous System    neopallial surface
  • Nervous SystemCranial nerve distribution resembles
  • Nervous System    adult pattern
  • Nervous SystemDura lines entire vertebral canal
  • Nervous SystemFasciculus cuneatus and fasciculus
  • Nervous System    gracilis form the decussation of the
  • Nervous System    medial lemnisci
  • Nervous SystemHandedness
  • Nervous SystemHippocampus reaches temporal pole
  • Nervous SystemInferior and superior cerebellar
  • Nervous System    peduncles
  • Nervous SystemInsula
  • Nervous SystemMost cisterns present
  • Nervous SystemPons
  • Nervous SystemPrincipal nucleus of inferior olivary
  • Nervous System    nuclei
  • Nervous SystemPyramidal decussations
  • Nervous SystemSubarachnoid space
  • Nervous SystemSuprapineal recess
  • Special SensesOptic tract reaches ventral portion
  • Special Senses    of lateral geniculate body
  • Special SensesRetina with 4 of the10 layers found
  • Special Senses    in adult
  • CardiovascularBlood supply to the brain closely
  • Cardiovascular    resembles adult pattern
  • CardiovascularSuperior sagittal sinus
  • CardiovascularSuperior vena cava
  • RespiratoryPseudoglandular stage begins
  • GastrointestinalLongitudinal muscles in esophagus
  • MusculoskeletalForamen magnum (wide)
  • EndocrineLeydig cells (testes) produce
  • Endocrine    testosterone
  • Growth ParametersCrown-heel length 4.3 cm
   
Unit 10:   9 to 10 Weeks
     
  • (10 weeks):
  • Nervous SystemCommissure of the fornix
  • FacialPalatine tonsils
  • FacialTooth buds (secondary teeth)
  • CardiovascularLeft brachiocephalic vein
  • GastrointestinalPhysiologic herniation ends
  • MusculoskeletalOssification underway in most bones
  • SkinEpidermis with periderm,
  • Skin    intermediate, and basal layers
  • Growth ParametersCrown-heel length 7.5 cm
  • (10 weeks - 12 weeks):
  • Blood & ImmuneLangerhans cells enter epidermis
   
Unit 12:   11 to 12 Weeks
     
  • (12 weeks):
  • Nervous SystemCorpus callosum
  • Nervous SystemCrura cerebri
  • Nervous SystemMyelination in spinal cord
  • FacialAll facial muscles in final positions
  • GastrointestinalBile production begins in liver
  • GastrointestinalBowel movements
  • SkinSebaceous glands
  • Growth ParametersCrown-heel length 12 cm
  • Growth ParametersHead circumference 10 cm
   
Unit 14:   4 to 5 Months
     
  • (18 weeks):
  • SkinApocrine sweat glands
  • SkinEccrine sweat glands
  • (19 weeks):
  • Nervous SystemSulci on surface of cerebral
  • Nervous System    hemispheres
  • SkinMelanin production
  • (20 weeks):
  • RespiratorySurfactant production (low levels)
  • GastrointestinalPeyer's patches
  • Growth ParametersCrown-heel length 28 cm
  • Growth ParametersHead circumference 20 cm
   
Unit 16:   6 to 7 Months
     
  • (25 weeks):
  • GastrointestinalIntestinal lining contains all adult
  • Gastrointestinal    cell types
  • (26 weeks):
  • RespiratoryTerminal sac stage begins
  • (28 weeks):
  • Growth ParametersCrown-heel length 39.5 cm
   
Unit 18:   8 to 9 Months
     
  • (36 weeks):
  • RespiratorySurfactant production accelerates
  • Growth ParametersBrain weight 300 grams
  • Growth ParametersCrown-heel length 48.5 cm